1. Why am I using PARIET?

PARIET contains the active ingredient rabeprazole sodium. PARIET is used to treat gastro-oesophageal reflux disease, peptic ulcers, and chronic gastritis in adults.

For more information, see Section 1. Why am I using PARIET? in the full CMI.

2. What should I know before I use PARIET?

Do not use if you have ever had an allergic reaction to rabeprazole sodium or any of the ingredients listed at the end of the CMI.

Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.

For more information, see Section 2. What should I know before I use PARIET? in the full CMI.

3. What if I am taking other medicines?

Some medicines may interfere with PARIET and affect how it works.

A list of these medicines is in Section 3. What if I am taking other medicines? in the full CMI.

4. How do I use PARIET?

• Use PARIET exactly as your doctor has prescribed. The dose of PARIET tablets is usually 20 mg but may vary from 10 mg to 40 mg per day depending on what condition you are being treated for and how severe it is.
• The usual dose is one tablet, to be taken once daily at the same time each day. Always swallow PARIET tablets whole.

More instructions can be found in Section 4. How do I use PARIET? in the full CMI.

5. What should I know while using PARIET?

For more information, see Section 5. What should I know while using PARIET? in the full CMI.

6. Are there any side effects?

PARIET is usually well tolerated but tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking PARIET. The common side effects include headache, dizziness, diarrhoea, nausea, abdominal pain, wind, vomiting, constipation, runny or blocked nose, sore throat, cough, non-specific pain, back pain, muscle pain, rash, muscle weakness, physical weakness or lack of energy, flu-like syndrome, infection, insomnia, and chest pain. The serious side effects include allergic reactions; frequent infections; urinary tract infection, vision or taste disturbance, depression, feeling dizzy, faint, lightheaded or weak (hypotension), pain or indigestion, begin to vomit blood or food, pass black (blood-stained) stools, symptoms of bowel inflammation such as severe (watery or bloody) diarrhoea, fever, abdominal pain or tenderness.

For more information, including what to do if you have any side effects, see Section 6. Are there any side effects? in the full CMI.

PARIET® Tablets

Active ingredient(s): rabeprazole sodium

Consumer Medicine Information (CMI)

This leaflet provides important information about using PARIET. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using PARIET.

Where to find information in this leaflet:

1. Why am I using PARIET?

PARIET contains the active ingredient rabeprazole sodium. PARIET belongs to a group of medicines called proton pump inhibitors (PPIs). PARIET works by decreasing the amount of acid the stomach makes to give relief from the symptoms and allow healing to take place. Your food will still be digested in the same way.

PARIET is used to treat:

• Gastro-oesophageal reflux disease:
  PARIET is used to treat gastro-oesophageal reflux disease (GORD), commonly known as 'reflux'. This can be caused by food and acid from the stomach flowing the wrong way (reflux) back up the food pipe, also known as the oesophagus.
  Reflux can cause a burning sensation in the chest, rising up to the throat, also known as heartburn. PARIET is also used to help stop gastro-oesophageal reflux disease from coming back or relapsing.
• Peptic Ulcers:
  PARIET is used to treat peptic ulcers. Depending on the position of the ulcer it is called a gastric or duodenal ulcer. A gastric ulcer occurs in the stomach. A duodenal ulcer occurs in the duodenum, which is the tube leading out of the stomach.
  These ulcers can be caused by too much acid being made in the stomach.
  Most people who have a peptic ulcer also have bacteria called Helicobacter pylori in their stomach. Your doctor may also prescribe a course of antibiotics (clarithromycin and amoxycillin) for you. When PARIET is taken with antibiotics, the combination therapy will kill the Helicobacter pylori and let your ulcer heal.
• Chronic Gastritis:
  The presence of the bacteria Helicobacter pylori may cause the stomach to become inflamed, resulting in pain, nausea and vomiting; all of which are signs of chronic gastritis.
  When PARIET tablets are taken with antibiotics, they will help kill Helicobacter pylori and allow the stomach to heal.

Your doctor may have prescribed PARIET for another reason. Ask your doctor if you have any questions about why PARIET has been prescribed for you.

2. What should I know before I use PARIET?

Warnings

Do not use PARIET if:

• you are allergic to rabeprazole sodium, other PPIs (omeprazole, esomeprazole, lansoprazole, pantoprazole), or any of the ingredients listed at the end of this leaflet.
• Always check the ingredients to make sure you can use this medicine.
• the packaging is torn or shows signs of tampering.

Check with your doctor if you:

• have now, or have had in the past, liver problems

• take any medicines for any other condition

During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?

Pregnancy and breastfeeding

Check with your doctor if you are pregnant or intend to become pregnant.

Talk to your doctor if you are breastfeeding or intend to breastfeed. It is not known if PARIET passes into breast milk.

Children and adolescents

PARIET should not be given to children under 18 years of age. Safety and effectiveness of PARIET in children has not been established.

3. What if I am taking other medicines?

Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may interfere with PARIET and affect how it works.

Do not take PARIET and tell your doctor or pharmacist if you are taking any of the following:

• atazanavir, a medicine used (with other antiretrovirals) to treat HIV-1 infection.
• clopidogrel, an antiplatelet medicine.

You should not take PARIET while taking these medicines.

Also tell your doctor or pharmacist if you are taking any of the following:

• cyclosporin, a medicine used to treat several conditions including prevention of graft rejection following kidney, liver or heart transplantation; severe, active rheumatoid arthritis; severe skin diseases; kidney disease where other treatments have failed.
• methotrexate, a medicine used to treat some kinds of cancer. It is also used to treat psoriasis (skin disease) and rheumatoid arthritis.
• digoxin, a medicine used to treat heart problems.
• ketoconazole, a medicine used to treat fungal infections.
• mycophenolate mofetil, a medicine used to prevent organ rejection following kidney, liver or heart transplants.
• clarithromycin, a medicine used to treat infections.

Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect PARIET.

4. How do I use PARIET?

How much to take

• The usual dose is one tablet to be taken once daily.
• The dose of PARIET tablets is usually 20 mg but may vary from 10 mg to 40 mg per day depending on what condition you are being treated for and how severe it is.
• For treating Helicobacter pylori infections in combination with antibiotics (clarithromycin and amoxycillin), the usual dose is one 20mg tablet twice daily, morning and evening, for 7 days.
• Follow the instructions provided and use PARIET until your doctor tells you to stop.

When to take PARIET

• PARIET should be taken at the same time each day.

How to take PARIET

• PARIET should be swallowed whole, with a glass of water or other liquid.
• Do NOT crush or chew the tablets. They have a special coating, which protects them from the acid in your stomach. If the coating is broken by chewing, the tablets may not work.
• It does not matter if you take PARIET with food or on an empty stomach

If you forget to use PARIET

If you miss your dose at the usual time, take it as soon as you remember and then continue to take it as you would normally.

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Do not take a double dose to make up for the dose you missed.

If you use too much PARIET

If you think that you have used too much PARIET, you may need urgent medical attention.

You should immediately:

• phone the Poisons Information Centre
  (by calling 13 11 26), or
• contact your doctor, or
• go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.

5. What should I know while using PARIET?

Things you should do

• Use PARIET exactly as your doctor has prescribed.
• Tell your doctor if you need to have a specific blood test (Chromogranin A) while you are taking PARIET. It may affect the results of this test.

Call your doctor straight away if you:

• become pregnant while you are taking PARIET

Remind any doctor, dentist or pharmacist you visit that you are using PARIET.

Things you should not do

• Do not use PARIET to treat any other complaints unless your doctor says to.
• Do not give this medicine to anyone else, even if they have the same symptoms as you.
• Do not crush or chew the tablets.
• Do not give PARIET to children.

Driving or using machines

Be careful before you drive or use any machines or tools until you know how PARIET affects you.

PARIET may cause dizziness in some people.

Looking after your medicine

• Do not take PARIET tablets out of the blister pack until it is time to take them. PARIET tablets are packaged in a double-sided aluminium blister strip. If you take them out of the blister they may not keep well.
• Keep PARIET tablets in a cool dry place where the temperature is below 25°C. Do not keep PARIET in the refrigerator or freezer.

Follow the instructions in the carton on how to take care of your medicine properly.

Store it in a cool dry place away from moisture, heat or sunlight; for example, do not store it:

• in the bathroom or near a sink, or
• in the car or on window sills.

Keep it where young children cannot reach it.

A locked cupboard at least one-and-a-half metres (1.5 m) above the ground is a good place to store medicines.

Getting rid of any unwanted medicine

If you no longer need to use this medicine or it is out of date, take it to any pharmacy for safe disposal.

Do not use this medicine after the expiry date.

6. Are there any side effects?

All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.

See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions about side effects.

Less serious side effects

Serious side effects

Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell.

Other side effects not listed here may occur in some people and are more likely to arise from the ulcer itself rather than the treatment.

Reporting side effects

After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at www.tga.gov.au/reporting-problems. By reporting side effects, you can help provide more information on the safety of this medicine.

Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines.

7. Product details

This medicine is only available with a doctor's prescription.

What PARIET contains

Do not take this medicine if you are allergic to any of these ingredients.

The tablets do not contain lactose or gluten.

What PARIET looks like

PARIET 10 mg tablets are pink and have "E241" in black ink on one side (Aust R 76185).

PARIET 10 mg tablets are available in blister packs of 7, 28 and 30 tablets.

PARIET 20 mg tablets are pale yellow and have "E243" in red ink on one side (Aust R 76186).

PARIET 20 mg tablets are available in blister packs of 7, 28 and 30 tablets.

Not all pack sizes may be marketed.

Who distributes PARIET

JANSSEN-CILAG Pty Ltd

1-5 Khartoum Rd

Macquarie Park NSW 2113 Australia

Telephone: Toll Free 1800 226 334

This leaflet was prepared in August 2025.

PARIET® is a trademark of Eisai Ltd.